Anti-fatigue supplements can be a welcome addition if you experience fatigue and want to have more energy. Below you will find our top 5, in no particular order, of the best supplements against fatigue.

#1 Alpha-lipoic acid (ALA)

ALA is an antioxidant found in the mitochondria (energy cells) of our cells and is present in a number of dietary sources. ALA functions as a cofactor in the metabolism of energy by the mitochondria. It helps enzymes convert nutrients (carbohydrates) from food into energy (ATP) that is used by every cell in the body. Studies have found that dietary ALA consumption or supplementation may be associated with better mitochondrial function and a decrease in insulin resistance (1)

Consuming more ALA from organ meats and broccoli or through a Alpha Lipoic Acid supplement can help increase energy, improve performance, and promote cognitive health by increasing mitochondrial synthesis. ALA stimulates energy metabolism by modulating the expression of PGC-1 alpha, a regulator of mitochondrial function. Mitochondria are the site of energy production that all human cells need and are involved in virtually every function in the body.

#2 Quercetin

Quercetin is a vegetable polyphenol that can be found in foods with antioxidant and anti-inflammatory properties. It protects the body against unstable compounds called free radicals. Quercetin is found in several plant foods, such as red onion, apples, green tea, and berries. Research indicates that Quercetin supplements has important anti-fatigue and vasoprotective effects (2). Quercetin also improves energy through its positive influence on immunity.

#3 L-Citrulline

L-Citrulline is an amino acid and is used as a supplement for sports performance and cardiovascular health. Supplementation with L-Citrulline can help reduce fatigue and improve endurance during exercise. Citrulline has mainly been studied in a sports or exercise context. It can increase the time it takes for a person to become tired during exercise. One way citrulline achieves this is by increasing blood flow to the muscles during exercise, helping them to last longer when they work hard during intense exercise. One study looked specifically at men who complained of fatigue. Supplementation with 6 g of citrulline per day for 22 days resulted in the men reporting less fatigue (3)

#4 Q10

Q10 only helps with energy levels and oxidative stress if you have low CoQ10 levels in the first place, which many people experience as they age! CoQ10, short for coenzyme Q10, is a crucial factor in cellular energy production and is a powerful antioxidant that is useful as a supplement against fatigue (4) . It is found in all our cells, but in higher concentrations in our brain, heart, and kidneys. CoQ10 is produced by our bodies, but decreases as we age, which can lead to a need for supplements

Insufficient amounts of CoQ10 limit the cells' ability to divide and perform their functions, which can lead to fatigue in the long term. Deficiency has been shown to be linked to some chronic diseases, but there are no safety concerns with daily supplementation. In general a Coenzyme Q10 supplement becomes more useful as you get older (from 20 years) to help us feel good, less tired and continue to perform at our best.

#5 NMN